Using MRI Scans to Inform Individualized Neuromodulation Interventions in Major Depression Disorders with and without Comorbidities

This research study uses MRI scans to help investigators learn more about potential individual differences in adult brains that could inform placement for neuromodulation clinical treatments and research studies. The study is seeking participants who have been referred to neuromodulation treatments, such as Deep Brain Stimulation (DBS) Electroconvulsive Therapy (ECT), Prefrontal Cortical Stimulation (PCS), or Vagus Nerve Stimulation (VNS), by a psychiatrist or other provider specifically to treat or study a mental health condition. 

During the research study, participants will be asked to complete 1 pre-treatment MRI, lasting up to three hours, to complete structural and functional MRI scans. Participants will also be asked to consent to sharing mental health diagnosis and treatment records, or complete mental health assessments to confirm diagnoses and symptom status. Some participants may qualify to complete additional scans while receiving neuromodulation therapies, or after their completion. If so, they may be asked to complete additional scans no more than three times in any one year of treatment.

Study Inclusion Criteria: Participants must:

• Be age 18 or older
• Be seeking or referred for neuromodulation interventions for clinical care or research studies at the St Louis Park Clinic Interventional Psychiatry Program
• Read English

Study Exclusion Criteria: Participants must not:

• Be unable or unwilling to consent
• Be ineligible to complete MRI

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