The RECOVER Research Study - Sponsored by LivaNova

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1/3 people with depression have what is called ‘treatment-resistant’ depression, which means they have tried several treatments without success. If several types of treatment haven’t worked for you, or have not worked well enough, joining the RECOVER Study could give you a new opportunity to improve your quality of life. RECOVER is a new research study for people with difficult-to-treat depression and it involves the VNS therapy.

VNS stands for Vagus Nerve Stimulation. VNS Therapy is a treatment for people with depression who have not been helped enough by other types of treatment, such as antidepressant medications (pills, tablets and anti-depressant nasal sprays), psychotherapy (talking therapy), transcranial magnetic stimulation (TMS) and electroconvulsive therapy (ECT). VNS Therapy was approved by the FDA in 2005 as a safe and effective treatment option for treatment-resistant depression (TRD).

Location of Vagus Nerve electrode and implantable pulse generator in computer generated human


Even though VNS Therapy is FDA-approved, Medicare and other insurers do not routinely cover it. To change this, many of the nation’s top depression experts worked together to help design the RECOVER study. If the results are like past studies, this may provide the proof Medicare and insurance companies need to start to cover it.


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UMN IRB Number: SITE00000818; STUDY00009412

To participate in the RECOVER Research study, you must be:

  • 18 years or older
  • Enrolled in Medicare or Medicare Advantage
  • Experiencing depression or bipolar depression that has not adequately responded to at least 4 antidepressant treatments
A patient with depression looking forward with a partner placing a hand on their shoulder

To learn more about the RECOVER study, please contact the Interventional Psychiatry Lab study team, overseen by Dr. Ziad Nahas, Department of Psychiatry and Behavioral Studies, University of Minnesota. 

952-525-4505 OR [email protected]